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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K6 All Species: 27.58
Human Site: Y234 Identified Species: 50.56
UniProt: P52564 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52564 NP_002749.2 334 37492 Y234 P E L N Q K G Y S V K S D I W
Chimpanzee Pan troglodytes Q9XT09 393 43428 G281 M F G C Q V E G D A A E T P P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851023 334 37590 Y234 P E L N Q K G Y S V K S D I W
Cat Felis silvestris
Mouse Mus musculus P70236 334 37414 Y234 P E L N Q K G Y S V K S D I W
Rat Rattus norvegicus Q4KSH7 419 47517 Y299 P D P T K P D Y D I R A D V W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511595 352 40240 Y250 P E L N Q K G Y N V K S D V W
Chicken Gallus gallus Q90891 398 44059 G287 P V V D G A E G E S H S V S P
Frog Xenopus laevis Q07192 446 50082 Y331 P S A S R Q G Y D V R S D V W
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 Y261 P E T N Q K G Y N V K S D I W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477162 334 38176 Y227 P Q G N P A Q Y D I R S D V W
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20347 363 41178 R249 S S D K Y D V R S D V W S L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7U9 363 39830 I250 K Y G N K S D I W S L G L V V
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 V543 P D R A T Y T V Q S D I W S L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32 N.A. 98.8 N.A. 97.9 38.6 N.A. 75.2 34.4 43.5 80.6 N.A. 58.6 N.A. 38.2 N.A.
Protein Similarity: 100 47.8 N.A. 99 N.A. 99 53.7 N.A. 85.5 51.5 56 85.8 N.A. 74.8 N.A. 56.2 N.A.
P-Site Identity: 100 6.6 N.A. 100 N.A. 100 26.6 N.A. 86.6 13.3 46.6 86.6 N.A. 40 N.A. 6.6 N.A.
P-Site Similarity: 100 6.6 N.A. 100 N.A. 100 66.6 N.A. 100 26.6 80 93.3 N.A. 66.6 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 31.9 24.2 N.A.
Protein Similarity: N.A. N.A. N.A. 53.1 36 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 16 0 0 0 8 8 8 0 0 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 8 8 0 8 16 0 31 8 8 0 62 0 0 % D
% Glu: 0 39 0 0 0 0 16 0 8 0 0 8 0 0 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 24 0 8 0 47 16 0 0 0 8 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 0 16 0 8 0 31 0 % I
% Lys: 8 0 0 8 16 39 0 0 0 0 39 0 0 0 0 % K
% Leu: 0 0 31 0 0 0 0 0 0 0 8 0 8 8 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 54 0 0 0 0 16 0 0 0 0 0 0 % N
% Pro: 77 0 8 0 8 8 0 0 0 0 0 0 0 8 16 % P
% Gln: 0 8 0 0 47 8 8 0 8 0 0 0 0 0 0 % Q
% Arg: 0 0 8 0 8 0 0 8 0 0 24 0 0 0 0 % R
% Ser: 8 16 0 8 0 8 0 0 31 24 0 62 8 16 0 % S
% Thr: 0 0 8 8 8 0 8 0 0 0 0 0 8 0 0 % T
% Val: 0 8 8 0 0 8 8 8 0 47 8 0 8 39 8 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 8 8 0 62 % W
% Tyr: 0 8 0 0 8 8 0 62 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _